Pruritus, anxiety, Preoperative sedation, Nausea and Vomiting (off label)
Side Effects
Common adverse effects are as follow: Anticholinergic: Dry mouth Central nervous system: Drowsiness (usually transitory and may disappear in a few days of continued therapy or upon reduction of the dose), involuntary motor activity (tremor, convulsions) usually with doses considerably higher than those recommended Clinically significant respiratory depression has not been reported at recommended doses.
Dose
- For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested: in adults, 50 to 100 mg q q6hr.; children under 6 years, 50 mg daily in divided doses and over 6 years, 50 to 100 mg daily in divided doses.
- For use in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses, and in histamine-mediated pruritus: in adults, 25 mg q8hr or q6h.; children under 6 years, 50 mg daily in divided doses and over 6 years, 50 to 100 mg daily in divided doses.
- As a sedative when used as a premedication and following general anesthesia: 50 to 100 mg in adults, and 0.6 mg/kg in children.
Warning
• May cause CNS depression resulting in drowsiness; avoid driving or operating dangerous machinery
• May cause over-sedation and confusion in elderly patients; start on lower doses and monitor closely.
Potentiates CNS depression with alcohol, other CNS depressants (for example narcotics, non-narcotic analgesics, barbiturates); reduce dose of these agents.
